The World's First
Approved Bee Vaccine

More Info

Dalan’s platform technology is delivered orally. The vaccine is ingested by the Queen Bee, and vaccine fragments are passed on to larvae for protection against diseases.

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How it works

The Dalan vaccine technology exposes queen bees to inactive (i.e., “dead”) bacteria, which enables the larvae hatched in the hive to resist infection.

Dalan can assist in creating a custom vaccination program for your operation that is compatible with a variety of commonly used queen cages.

  • (1) The vaccine is mixed with queen candy.

  • (2) Worker bees consume the vaccine with the queen candy which is then digested and transferred to the glands that produce the royal jelly.

  • (3) Worker bees feed the royal jelly containing the vaccine to the queen.

  • (4) The queen digests the royal jelly and the vaccine is transferred to her ovaries. She is then released into the hive.

  • Close-up of a honeybee hive with many bees on honeycomb cells and one bee marked with a yellow dot on its head.

    (5) The vaccine is transferred to the developing eggs.

  • Dalan Biosciences Close-up of honeycomb with honey inside the cells.

    (6) The developing larvae (now vaccinated) are more immune to infection as they hatch.

Our Methods

Dalan Animal Health is using its platform technology to develop vaccines for multiple diseases.

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Proven Safety

Queen survival. In tests, immune priming showed no negative impact on queen fitness.

Dickel F, Bos NMP, Hughes H, Martín-Hernández R, Higes M, Kleiser A and Freitak D (2022) The oral vaccination with Paenibacillus larvae bacterin can decrease susceptibility to American Foulbrood infection in honey bees–A safety and efficacy study. Front. Vet. Sci. 9:946237. doi: 10.3389/fvets.2022.946237
Proven Safety

Honey quality. Our tests also show no negative impact on honey. Our product is chemical free, non-GMO, and organic.

Our vaccine is conditionally licensed by the USDA-CVB and CFIA-CCVB for the vaccination of queen honeybees to prime larvae against mortality due to Paenibacillus larvae.

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In field trials conducted across the U.S, we have correlated a decrease in viral pathogens such as Deformed Wing Virus (DWV) with vaccinated colonies.

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Bee Health
Scientific Advisors

  • Dalan Co-Founder

    In 2018, Dalial joined CEO Annette Kleiser to found Dalan based on groundbreaking research being done at the University of Helsinki, Finland. Dalial has almost two decades of experience in research with a specific focus on insect immunology and physiology. She currently holds an Assistant Professor position at the Karl Franzens University Graz, Institute of Biology. She studied biology (Zoology and Animal Ecology) at the University of Tartu and earned her PhD at the Max Planck Institute of Chemical Ecology in Jena.

  • Gene E. Robinson is the Director of the Carl R. Woese Institute for Genomic Biology. He holds a Swanlund Chair at the University of Illinois at Urbana-Champaign, where he has been since 1989. He also holds affiliate appointments in the Department of Cell & Developmental Biology, the Program in Ecology, Evolution and Conservation Biology, and the Beckman Institute of Science and Technology. He received his Ph.D. from Cornell University and was an NSF Postdoctoral Fellow at Ohio State University.

“What this team is accomplishing will be
the long term future of beekeeping. It’s the change and the direction that the industry has badly needed for some time and has patiently waited for.”

Chris Gates,
Flying Bee INC.